Sulfonium Salts as Alkylating Agents for Palladium-Catalyzed Direct Ortho Alkylation of Anilides and Aromatic Ureas

Org Lett. 2018 Feb 2;20(3):676-679. doi: 10.1021/acs.orglett.7b03813. Epub 2018 Jan 12.

Abstract

A novel method for the ortho alkylation of acetanilide and aromatic urea derivatives via C-H activation was developed. Alkyl dibenzothiophenium salts are considered to be new reagents for the palladium-catalyzed C-H activation reaction, which enables the transfer of methyl and other alkyl groups from the sulfonium salt to the aniline derivatives under mild catalytic conditions.

Publication types

  • Research Support, Non-U.S. Gov't