Effects of hypertonic saline, HAES and dimethylsulphoxide on free oxygen radicals in haemorrhagic shock oxygen radicals in haemorrhagic shock

Ulus Travma Acil Cerrahi Derg. 2003 Jul;9(3):154-9.

Abstract

Background: The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia.

Methods: Forty New Zealand type rabbits were divided into four groups as C (control), I (hypertonic saline), H (HAES) and D (Dimethylsulphoxide-DMSO). Haemorrhagic shock was induced by bleeding from carotid artery. Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO. Thiobarbituric acid reactive substances (TBARS) and lactate levels in blood, liver and small bowel samples were measured.

Results: There were no significant differences among the groups tissue and plasma TBARS and lactate levels.

Conclusion: Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.

MeSH terms

  • Animals
  • Dimethyl Sulfoxide / administration & dosage
  • Dimethyl Sulfoxide / therapeutic use*
  • Disease Models, Animal
  • Erythrocytes / metabolism
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / therapeutic use*
  • Infusions, Intravenous
  • Intestine, Small / metabolism
  • Lactic Acid / blood
  • Lactic Acid / metabolism
  • Liver / metabolism
  • Rabbits
  • Saline Solution, Hypertonic / administration & dosage
  • Saline Solution, Hypertonic / therapeutic use*
  • Shock, Hemorrhagic / therapy*
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Free Radical Scavengers
  • Saline Solution, Hypertonic
  • Thiobarbituric Acid Reactive Substances
  • Lactic Acid
  • Dimethyl Sulfoxide