PURPOSE:Because toxicities associated with chemotherapy and radiotherapy canadversely
affect short- and long-term patient quality of life, can limitthe dose and duration of treatment, …

Bone marrow (BM) metastasis remains one of the main causes of death associated with solid
tumors as well as multiple myeloma (MM). Targeting the BM niche to prevent or modulate …

Background Ecteinascidin-743 (ET-743), a member of the ecteinascidin family selected for
clinical development, is a tetrahydroisoquinolone alkaloid isolated from the marine ascidian, …

Employing in vitro selection techniques, we have generated biostable RNA-based compounds,
so-called Spiegelmers, that specifically bind n-octanoyl ghrelin, the recently discovered …

CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting
signal sequences. Leptomycin B (LMB), a well-known CRM1 inhibitor, possesses strong …

It was the aim of the study to check ethanolic and CO 2 extracts from Humulus lupulus for
sedating activity. Both preparations reduced the spontaneous locomotor activity, increased the …

Exome sequencing analysis of over 2,000 children with complex malformations of cortical
development identified five independent (four homozygous and one compound heterozygous) …

Oncogene amplification in tumor cells results in the overexpression of proteins that confer a
growth advantage in vitro and in vivo. Amplified oncogenes can reside intrachromosomally, …

Background Pancreatic cancer retains a poor prognosis among the gastrointestinal cancers.
It affects 230,000 individuals worldwide, has a very high mortality rate, and remains one of …

NOX‐A12 is a PEGylated mirror‐image oligonucleotide (a so‐called Spiegelmer) that binds
to CXCL12 (stromal cell–derived factor‐1, SDF‐1) with high affinity thereby inhibiting …