The wnt/β‐catenin signaling pathway: A potential therapeutic target in the treatment of triple negative breast cancer

TD King, MJ Suto, Y Li - Journal of cellular biochemistry, 2012 - Wiley Online Library
Breast cancer continues to be a serious health problem particularly in developed countries.
Of particular concern is triple negative breast cancer (TNBC) which does not respond well to …

Frizzled7 as an emerging target for cancer therapy

TD King, W Zhang, MJ Suto, Y Li - Cellular signalling, 2012 - Elsevier
Wnt proteins are secreted glycoproteins that bind to the N-terminal extra-cellular cysteine-rich
domain of the Frizzled (Fzd) receptor family. The Fzd receptors can respond to Wnt …

Secundum atrial septal defect: nonoperative closure during cardiac catheterization

TD King, SL Thompson, C Steiner, NL Mills - Jama, 1976 - jamanetwork.com
A 17-year-old girl had clinical and cardiac catheterization findings compatible with a
secundum atrial septal defect. During cardiac catheterization, the atrial septal defect was …

Nonoperative closure of atrial septal defects

TD King, NL Milk - Surgery, 1974 - surgjournal.com
Atrial septal defects (ASD) were created in 13 adult dogs. An experimental technique and
apparatus have been developed for transvenous closure of the defects. The procedure …

Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3β and attenuated by lithium

TD King, GN Bijur, RS Jope - Brain research, 2001 - Elsevier
The compound 1-methyl-4-phenylpyridinium (MPP) is a selective inhibitor of mitochondrial
complex I, and is widely used in model systems to elicit neurochemical alterations that may …

Nonoperative closure of left-to-right shunts

NL Mills, TD King - The Journal of thoracic and cardiovascular surgery, 1976 - Elsevier
Efforts to close left-to-right shunts at Ochsner Medical Institutions have been directed toward
atrial septal defects (ASD) and patent ductus arteriosus (PDA). PDA's were constructed in …

Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells

W Lu, C Lin, TD King, H Chen, RC Reynolds, Y Li - Cellular signalling, 2012 - Elsevier
Silibinin is a natural compound isolated from milk thistle seed extracts, and has traditionally
been used as a hepatoprotectant. A number of studies have also established the cancer …

Optimal environmental dispatching of electric power systems via an improved Hopfield neural network model

TD King, ME El-Hawary… - IEEE Transactions on …, 1995 - ieeexplore.ieee.org
This paper examines the usefulness and specifics of the Hopfield neural network as applied
to optimal economic/environmental dispatching of thermal generating units in an electric …

AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3

TD King, L Song, RS Jope - Biochemical pharmacology, 2006 - Elsevier
AMP-activated protein kinase (AMPK) is a key cellular sensor of reduced energy supply that
is activated by increases in the cellular ratio of AMP/ATP. Phenformin and 5-aminoimidazole-…

[HTML][HTML] Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition

P De Sarno, SA Shestopal, TD King… - Journal of Biological …, 2003 - ASBMB
The impact of muscarinic receptor stimulation was examined on apoptotic signaling induced
by DNA damage, oxidative stress, and mitochondrial impairment. Exposure of human …