User profiles for P. Kearns

Pamela Kearns

Professor of clinical paediatric oncology, University of Birmingham
Verified email at bham.ac.uk
Cited by 4964

[HTML][HTML] Challenges to curing primary brain tumours

…, EC Holland, DTW Jones, JA Joyce, P Kearns… - Nature reviews Clinical …, 2019 - nature.com
Despite decades of research, brain tumours remain among the deadliest of all forms of cancer.
The ability of these tumours to resist almost all conventional and novel treatments relates, …

[BOOK][B] Generic Skills for the New Economy. Review of Research.

P Kearns - 2001 - ERIC
The generic skills needed for the new economy were identified through a review of research
studies. First, the development of sets of key competencies/key skills in Great Britain, the …

Air–Liquid Interface In Vitro Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations

…, E Frejafon, P Hubert, L Gribaldo, P Kearns… - Applied in vitro …, 2018 - liebertpub.com
In vitro air–liquid interface (ALI) cell culture models can potentially be used to assess inhalation
toxicology endpoints and are usually considered, in terms of relevancy, between classic (…

[BOOK][B] Ladybirds.

M Majerus, P Kearns - 1989 - cabdirect.org
Ladybirds. Cookies on CAB Direct Like most websites we use cookies. This is to ensure that
we give you the best experience possible. Continuing to use www.cabdirect.org means you …

The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo

…, G Smith, JE Powell, Z Rudzki, P Kearns… - Blood, The Journal …, 2010 - ashpublications.org
The Ataxia Telangiectasia Mutated (ATM) gene is frequently inactivated in lymphoid malignancies
such as chronic lymphocytic leukemia (CLL), T-prolymphocytic leukemia (T-PLL), and …

Accelerated improvement of alcoholic liver disease with enteral nutrition

PJ Kearns, H Young, G Garcia, T Blaschke, G O'Hanlon… - Gastroenterology, 1992 - Elsevier
… A power analysis predicted an 80% chance of detecting a 25% change in antipyrine
clearance at the P < 0.05 leve1 with 16 patients in each group. Twenty-five patients per group …

Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice

…, S Varadharaj, J Lian, PN Kearns… - American Journal …, 2011 - journals.physiology.org
P value of <0.05 were considered to be statistically significant. … In control cells, TPA induced
marked activation with increased ROS generation [††P < 0.002 (DCF) and †††P < 0.001 (…

The COVID‐19 pandemic: a rapid global response for children with cancer from SIOP, COG, SIOP‐E, SIOP‐PODC, IPSO, PROS, CCI, and St Jude Global

…, S Luna‐Fineman, MS Khan, P Kearns… - Pediatric blood & …, 2020 - Wiley Online Library
The COVID‐19 pandemic is one of the most serious global challenges to delivering affordable
and equitable treatment to children with cancer we have witnessed in the last few decades…

[HTML][HTML] Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function

…, H Cui, A Samouilov, W Johnson, P Kearns… - Journal of biological …, 2007 - ASBMB
In endothelium, NO is derived from endothelial NO synthase (eNOS)-mediated l-arginine
oxidation. Endogenous guanidinomethylated arginines (MAs), including asymmetric …

The incidence of ventilator-associated pneumonia and success in nutrient delivery with gastric versus small intestinal feeding: a randomized clinical trial

PJ Kearns, D Chin, L Mueller, K Wallace… - Critical care …, 2000 - journals.lww.com
… and received an average of 67 ± 9% of their REE over the entire study (p > .1). The incidence
of aspiration pneumonia in this subset of patients did not differ between groups (p > .76). …