Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
MJ Selby, JJ Engelhardt, M Quigley, KA Henning… - Cancer immunology …, 2013 - AACR
… Note: MJ Selby and JJ Engelhardt contributed equally to this work. … MJ Selby is employed
(other than primary affiliation; eg, consulting) as a Director and has ownership interest (…
(other than primary affiliation; eg, consulting) as a Director and has ownership interest (…
Increased DNA vaccine delivery and immunogenicity by electroporation in vivo
…, L Leung, GR Otten, K Thudium, MJ Selby… - The Journal of …, 2000 - journals.aai.org
… However, electroporation treatment after vaccination with protein-based vaccines did not
result in an increase in immune responses (MJ Selby, C. Goldbeck, and JB Ulmer, unpublished …
result in an increase in immune responses (MJ Selby, C. Goldbeck, and JB Ulmer, unpublished …
In Vitro Characterization of the Anti-PD-1 Antibody Nivolumab, BMS-936558, and In Vivo Toxicology in Non-Human Primates
…, H Leblanc, RT Bunch, D Blanset, MJ Selby… - Cancer immunology …, 2014 - AACR
The programmed death-1 (PD-1) receptor serves as an immunologic checkpoint, limiting
bystander tissue damage and preventing the development of autoimmunity during inflammatory …
bystander tissue damage and preventing the development of autoimmunity during inflammatory …
[HTML][HTML] Synthesis of a novel hepatitis C virus protein by ribosomal frameshift
…, S Govindarajan, D Chien, MJ Selby… - The EMBO …, 2001 - embopress.org
Hepatitis C virus (HCV) is an important human pathogen that affects∼ 100 million people
worldwide. Its RNA genome codes for a polyprotein, which is cleaved by viral and cellular …
worldwide. Its RNA genome codes for a polyprotein, which is cleaved by viral and cellular …
Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice
…, C Woo, C Goldbeck, MJ Selby… - The Journal of …, 2000 - journals.aai.org
Intramuscular injection of DNA vaccines elicits potent humoral and cellular immune responses
in mice. However, DNA vaccines are less efficient in larger animal models and humans. …
in mice. However, DNA vaccines are less efficient in larger animal models and humans. …
The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences
GI Bell, MJ Selby, WJ Rutter - Nature, 1982 - nature.com
The sequence of the highly polymorphic region near the human insulin gene, which begins
363 base pairs before the start of transcription and extends upstream, indicated that it is …
363 base pairs before the start of transcription and extends upstream, indicated that it is …
Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat.
MJ Selby, ES Bain, PA Luciw… - Genes & …, 1989 - genesdev.cshlp.org
The human immunodeficiency virus (HIV-1)-encoded trans-activator (tat) increases HIV gene
expression and replication. Previously, we demonstrated that tat facilitates elongation of …
expression and replication. Previously, we demonstrated that tat facilitates elongation of …
Temporally distinct PD-L1 expression by tumor and host cells contributes to immune escape
Antibody blockade of programmed death-1 (PD-1) or its ligand, PD-L1, has led to unprecedented
therapeutic responses in certain tumor-bearing individuals, but PD-L1 expression's …
therapeutic responses in certain tumor-bearing individuals, but PD-L1 expression's …
[HTML][HTML] Preclinical development of ipilimumab and nivolumab combination immunotherapy: mouse tumor models, in vitro functional studies, and cynomolgus …
MJ Selby, JJ Engelhardt, RJ Johnston, LS Lu, M Han… - PloS one, 2016 - journals.plos.org
The monoclonal antibodies ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) have
shown remarkable antitumor activity in an increasing number of cancers. When combined, …
shown remarkable antitumor activity in an increasing number of cancers. When combined, …