A major goal of regenerative medicine is to stimulate tissue regeneration after traumatic
injury. We previously discovered that treating digit amputation wounds with BMP2 in neonatal …

Regeneration Biology is the study of organisms with endogenous regenerative abilities,
whereas Regenerative Medicine focuses on engineering solutions for human injuries that do not …

… We would also like to thank Morgan Kaufmann for permission to re-print portions of Dolan
& Smolensky (1988) in this article. This work has been partially supported by NSF grants IRI-…

While mammals cannot regenerate amputated limbs, mice and humans have regenerative
ability restricted to amputations transecting the digit tip, including the terminal phalanx (P3). In …

It is long-established that innervation-dependent production of neurotrophic factors is
required for blastema formation and epimorphic regeneration of appendages in fish and …

Intra-articular fractures (IAF) result in significant and prolonged inflammation, increasing the
chances of developing post-traumatic osteoarthritis (PTOA). Interleukin-one beta (IL-1β) and …

Mice are intrinsically capable of regenerating the tips of their digits after amputation. Mouse
digit tip regeneration is reported to be a peripheral nerve-dependent event. However, it is …

Extremity injuries occur frequently during warfare. While traditionally treated in definitive
clinics, the future battlefield is projected to be different in a variety of ways, and there will likely …

Epimorphic regeneration is a multitissue regeneration process where amputation does not
lead to scarring, but blastema formation and patterned morphogenesis for which cell plasticity …

Complete extremity regeneration in mammals is restricted to distal amputations of the digit
tip, the terminal phalanx (P3). In mice, P3 regeneration is mediated via the formation of a …