User profiles for A. Wengner

Amelia Wenger

Wildlife Conservation Society; University of Queensland
Verified email at uq.edu.au
Cited by 3469

[HTML][HTML] Area-based conservation in the twenty-first century

…, E Lewis, M Maron, BBN Strassburg, A Wenger… - Nature, 2020 - nature.com
Humanity will soon define a new era for nature—one that seeks to transform decades of
underwhelming responses to the global biodiversity crisis. Area-based conservation efforts, …

[HTML][HTML] Targeting DNA damage response in prostate and breast cancer

AM Wengner, A Scholz, B Haendler - International journal of molecular …, 2020 - mdpi.com
Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of the …

First-in-human trial of the oral ataxia telangiectasia and RAD3-related (ATR) inhibitor BAY 1895344 in patients with advanced solid tumors

…, F Meric-Bernstam, G Wilkinson, J Hreiki, AM Wengner… - Cancer discovery, 2021 - AACR
Oral BAY 1895344 was tolerable, with antitumor activity in heavily pretreated patients with
various advanced solid tumors, particularly those with ATM deleterious mutations and/or loss …

[PDF][PDF] Differential mobilization of subsets of progenitor cells from the bone marrow

SC Pitchford, RC Furze, CP Jones, AM Wengner… - Cell stem cell, 2009 - cell.com
G-CSF stimulates mobilization of hematopoietic progenitor cells (HPCs) from bone marrow
by disrupting the CXCR4/SDF-1α retention axis. We show here that distinct factors and …

The coordinated action of G-CSF and ELR+ CXC chemokines in neutrophil mobilization during acute inflammation

AM Wengner, SC Pitchford, RC Furze… - Blood, The Journal of …, 2008 - ashpublications.org
In this study, we have identified a unique combinatorial effect of the chemokines KC/MIP-2
and the cytokine granulocyte colony-stimulating factor (G-CSF) with respect to the rapid …

GREAT improves functional interpretation of cis-regulatory regions

…, SL Clarke, BT Schaar, CB Lowe, AM Wenger… - Nature …, 2010 - nature.com
We developed the Genomic Regions Enrichment of Annotations Tool (GREAT) to analyze
the functional significance of cis-regulatory regions identified by localized measurements of …

The Lab Oddity Prevails: Discovery of Pan‐CDK Inhibitor (R)‐S‐Cyclopropyl‐S‐(4‐{[4‐{[(1R,2R)‐2‐hydroxy‐1‐methylpropyl]oxy}‐5‐(trifluoromethyl)pyrimidin‐2‐yl …

…, J Schulze, A Hillisch, A Reichel, AM Wengner… - …, 2013 - Wiley Online Library
Lead optimization of a high‐throughput screening hit led to the rapid identification of
aminopyrimidine ZK 304709, a multitargeted CDK and VEGF‐R inhibitor that displayed a promising …

The novel ATR inhibitor BAY 1895344 is efficacious as monotherapy and combined with DNA damage–inducing or repair–compromising therapies in preclinical …

AM Wengner, G Siemeister, U Lücking, J Lefranc… - Molecular cancer …, 2020 - AACR
The DNA damage response (DDR) secures the integrity of the genome of eukaryotic cells.
DDR deficiencies can promote tumorigenesis but concurrently may increase dependence on …

Effects of Microplastic on Fitness and PCB Bioaccumulation by the Lugworm Arenicola marina (L.)

E Besseling, A Wegner, EM Foekema… - … science & technology, 2013 - ACS Publications
It has been speculated that marine microplastics may cause negative effects on benthic marine
organisms and increase bioaccumulation of persistent organic pollutants (POPs). Here, …

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

…, O Goldmann, T Binz, A Wegner… - Proceedings of the …, 2013 - National Acad Sciences
Immunoresponsive gene 1 (Irg1) is highly expressed in mammalian macrophages during
inflammation, but its biological function has not yet been elucidated. Here, we identify Irg1 as …