User profiles for A. X. Zhang

Amy X. Zhang

Assistant Professor, Computer Science & Engineering, University of Washington
Verified email at cs.uw.edu
Cited by 2338

Antibody-recruiting molecules: an emerging paradigm for engaging immune function in treating human disease

PJ McEnaney, CG Parker, AX Zhang… - ACS chemical …, 2012 - ACS Publications
Synthetic immunology, the development of synthetic systems capable of modulating and/or
manipulating immunological functions, represents an emerging field of research with …

Proteolysis‐targeting chimeras in drug development: a safety perspective

K Moreau, M Coen, AX Zhang, F Pachl… - British journal of …, 2020 - Wiley Online Library
Proteolysis‐targeting chimeras are a new drug modality that exploits the endogenous ubiquitin
proteasome system to degrade a protein of interest for therapeutic benefit. As the first‐…

Reduced default mode network functional connectivity in patients with recurrent major depressive disorder

…, AX Zhang, H Zhang, KR Zhang… - Proceedings of the …, 2019 - National Acad Sciences
Major depressive disorder (MDD) is common and disabling, but its neuropathophysiology
remains unclear. Most studies of functional brain networks in MDD have had limited statistical …

Tabletop x-ray ghost imaging with ultra-low radiation

AX Zhang, YH He, LA Wu, LM Chen, BB Wang - Optica, 2018 - opg.optica.org
Computational ghost imaging, in which an image is retrieved from a known patterned field
that illuminates an object and the total transmitted intensity therefrom, has seen great …

[HTML][HTML] Disrupted intrinsic functional brain topology in patients with major depressive disorder

…, AX Zhang, H Zhang, KR Zhang, L Zhang… - Molecular …, 2021 - nature.com
Aberrant topological organization of whole-brain networks has been inconsistently reported
in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. …

How do data science workers collaborate? roles, workflows, and tools

AX Zhang, M Muller, D Wang - Proceedings of the ACM on Human …, 2020 - dl.acm.org
Today, the prominence of data science within organizations has given rise to teams of data
science workers collaborating on extracting insights from data, as opposed to individual data …

[HTML][HTML] Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration

…, K Duong, CM Miller, S Posada, EJ Cobos, AX Zhang… - Neuron, 2014 - cell.com
The regenerative capacity of the peripheral nervous system declines with age. Why this occurs,
however, is unknown. We demonstrate that 24-month-old mice exhibit an impairment of …

A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules

AX Zhang, RP Murelli, C Barinka, J Michel… - Journal of the …, 2010 - ACS Publications
Prostate specific membrane antigen (PSMA) is a membrane-bound glutamate carboxypeptidase
overexpressed in many forms of prostate cancer. Our laboratory has recently disclosed …

Exploring lightweight interventions at posting time to reduce the sharing of misinformation on social media

F Jahanbakhsh, AX Zhang, AJ Berinsky… - Proceedings of the …, 2021 - dl.acm.org
When users on social media share content without considering its veracity, they may
unwittingly be spreading misinformation. In this work, we investigate the design of lightweight …

A structured response to misinformation: Defining and annotating credibility indicators in news articles

AX Zhang, A Ranganathan, SE Metz… - … Proceedings of the The …, 2018 - dl.acm.org
The proliferation of misinformation in online news and its amplification by platforms are a
growing concern, leading to numerous efforts to improve the detection of and response to …