User profiles for A. J. Zhang

Alex J. Zhang

Hanhai Investment Inc
Verified email at hanhaiinvestment.com
Cited by 955

[HTML][HTML] Attenuated replication and pathogenicity of SARS-CoV-2 B. 1.1. 529 Omicron

…, J Zhang, Y Hou, Y Wang, L Lu, JP Cai, AJ Zhang… - Nature, 2022 - nature.com
The Omicron (B.1.1.529) variant of SARS-CoV-2 emerged in November 2021 and is rapidly
spreading among the human population 1 . Although recent reports reveal that the Omicron …

Comparative replication and immune activation profiles of SARS-CoV-2 and SARS-CoV in human lungs: an ex vivo study with implications for the pathogenesis of …

…, KH Kok, KKW To, IHY Chan, AJ Zhang… - Clinical Infectious …, 2020 - academic.oup.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging
coronavirus that has resulted in more than 2 000 000 laboratory-confirmed cases including …

LLC resonant converter for front end DC/DC conversion

B Yang, FC Lee, AJ Zhang… - … Seventeenth Annual IEEE …, 2002 - ieeexplore.ieee.org
A new LLC resonant converter is proposed for front end DC/DC conversion in a distributed
power system. Three advantages are achieved with this resonant converter. First, ZVS turn on …

Simulation of the clinical and pathological manifestations of coronavirus disease 2019 (COVID-19) in a golden Syrian hamster model: implications for disease …

JFW Chan, AJ Zhang, S Yuan, VKM Poon… - Clinical infectious …, 2020 - academic.oup.com
Background A physiological small-animal model that resembles COVID-19 with low
mortality is lacking. Methods Molecular docking on the binding between angiotensin-converting …

[HTML][HTML] Infection of bat and human intestinal organoids by SARS-CoV-2

…, MC Chiu, X Zhao, D Wang, Y Wei, A Lee, AJ Zhang… - Nature medicine, 2020 - nature.com
A novel coronavirus—severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—emerged
in humans in Wuhan, China, in December 2019 and has since disseminated globally …

Surgical mask partition reduces the risk of noncontact transmission in a golden Syrian hamster model for coronavirus disease 2019 (COVID-19)

JFW Chan, S Yuan, AJ Zhang, VKM Poon… - Clinical infectious …, 2020 - academic.oup.com
Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is believed to be mostly transmitted by medium- to large-…

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction

SY Lau, P Wang, BWY Mok, AJ Zhang… - Emerging microbes & …, 2020 - Taylor & Francis
The emergence of SARS-CoV-2 has led to the current global coronavirus pandemic and
more than one million infections since December 2019. The exact origin of SARS-CoV-2 …

A colorimetric and fluorescent chemosensor for the detection of an explosive—2, 4, 6-trinitrophenol (TNP)

Y Peng, AJ Zhang, M Dong, YW Wang - Chemical communications, 2011 - pubs.rsc.org
A fluorescent and colorimetric receptor (L) for specific recognition of TNP was described.
The origins of this remarkable affinity was disclosed by the crystal structure of corresponding …

[HTML][HTML] Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

S Yuan, R Wang, JFW Chan, AJ Zhang, T Cheng… - Nature …, 2020 - nature.com
… All assays in aj were performed in triplicate and the data are presented as mean ± sd k,l,
Lineweaver–Burk plots showing the kinetics of inhibition on ATPase activity (k) and DNA-…

Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells

T Kim, J Davis, AJ Zhang, X He, ST Mathews - Biochemical and biophysical …, 2009 - Elsevier
Curcumin, the bioactive component of curry spice turmeric, and its related structures possess
potent anti-oxidant and anti-inflammatory properties. Several lines of evidence suggest that …